CLINICAL CASE
Sarcoidosis is a systemic granulomatosis of unknown etiology, characterized by non-caseating granulomas. The disease determines a distinctive but paradoxical immune state: an exaggerated immune response within the granulomas, in contrast to an anergic state and the appearance of opportunistic infections. We describe a case of coexistent cerebral cryptococcal infection in a immunocompetent individual with pulmonary sarcoidosis in AOU Siena.