The blood-brain barrier: Current research and novel therapeutic crossing approaches
Concept The normal functioning of the brain and the central nervous system is protected by the blood-brain barrier (BBB), which tightly regulates the brain homeostasis. Built to protect and preserve the correct functioning of the brain by avoiding the entrance of potentially damaging molecules, the BBB also prevents small and large therapeutic compounds from efficiently reaching the brain in case of disease. Indeed, the delivery of therapeutics to the brain cells faces many challenges that hinder the development and testing of novel therapies for brain and neurological disorders. Despite this, various strategies are currently being developed to improve the delivery of small and large molecules to the brain.
PhD students, researchers, and clinicians of all levels who are involved in brain and neurological diseases and/or in vascular biology.